The South American stars spent four years together at the Nou Camp, winning eight trophies, including the Champions League, in the process.
But they were separated over the summer when Paris Saint-Germain prised the Brazilian away in a world-record £198m deal.
Barcelona chiefs were fuming with the nature of the move and raised concerns with UEFA regarding Financial Fair Play regulations.
It’s clear that Barca suits’ annoyance at how Neymar’s departure happened has not impacted Messi’s opinion on the 25-year-old though.
The Argentine sent a heartfelt message to the PSG ace as part of Brazilian TV channel SBT’s secret santa event.
“We miss you here in Spain,” said Messi.
“In fact, I’ll always wish the best for you wherever you are and, sure enough, we will see each other soon, on or off the pitch.
“A big hug and take care of yourself.”
Neymar’s response confirmed the enduring admiration he has for Messi.
“Brother, thank you very much, for me you are an idol and also a great friend,” he said.