Adams, fighting on the undercard for Billy Joe Saunders’ undercard in Montreal, Canada this evening, hadn’t fought since May this year after making her professional debut a month earlier.
She came up against veteran Macedo who has competed in 30 bouts, winning 15 and four by knockout.
But the Uruguayan was no match for Adams as the two-time Olympic champion powered past her opponent in the third round with a barrage of ferocious punches.
Immediately after the fight Adams set her sights on a world title shot next year, but also revealed the heartbreak reason why she took seven months off.
“I’d taken some time out to be with my mum, but she said the best thing to do is to get a World title!” Adams said.
She added: “I think I made a statement tonight.
“I’m hoping for more fights, and a World title shot, in 2018!”