Tottenham kick-off the festive fixtures by hosting Southampton at Wembley (12.30pm) as Mauricio Pochettino looks to take three points from his former club.
West Ham have a trip to Bournemouth, Chelsea take on Brighton at Stamford Bridge while Manchester United host Burnley at Old Trafford.
Bottom-of-the-table Swansea City have a visit to Anfield in the late afternoon kick-off (5.30pm).
Newcastle have a tricky clash with league leaders Manchester City while Crystal Palace take on London rivals Arsenal.
But which side will take three points?
Take a look through the gallery above to see our Boxing Day predictions!