Chelsea are pushing Manchester United for the right to sit in second place over the Christmas period.
They beat Huddersfield on Tuesday night to maintain their good recent form.
Southampton sit 11th in the Premier League table and cannot move higher even with a win today.
They were hit 4-1 at home by Leicester on Wednesday after drawing successive games 1–1.
Saints will hope to get something from Stamford Bridge but in reality Chelsea are the favourites for this one.
Follow Chelsea vs Southampton below…