Mane started the thrilling 3-3 draw with Arsenal on Friday night. But the Senegalese attacking was one of four Liverpool changes for tonight’s clash with Swansea at Anfield.
After today’s games, Liverpool face Leicester on Saturday and then Burnley on Monday.
And Klopp says he wanted to freshen up his team during a busy period.
“It’s very important for us that we can line up like this. We could have lined up completely differently – they are all fit,” Klopp said.
“Sadio is fit but we thought we had to start in one way and then we need full strength over the full 95 minutes so we can make important changes.”
He added: “The most important thing is the game tonight, there’s no alternative [way] to think about it.
“We have to be as good as possible, as strong as possible, tonight and then we will see. A lot of things can happen but it’s not allowed to think about Leicester or Burnley.
“We need to make sure that we are ready for this game, that’s all.”