Real Madrid need three points to keep alive any hopes of retaining the La Liga title.
They trail Barca by 11 points but have a game in hand and sit down in fourth.
But victory, and winning their game in hand, would reduce the gap to just five points.
It would still be a tall order but defeat would end any chance they have.
And Real Madrid captain Ramos has a plan to shackle Barca.
Ramos is ready to ruff Lionel Messi up and turn the game into a war.
Diario Gol claim Ramos is ready to take the baton from Pepe – no longer at the club – from the days when he would man mark Messi under Jose Mourinho.
Pepe would clash with the Barcelona ace and haul him down at every opportunity.
And Ramos is ready to put his body on the line to help his side.
It goes against Zinedine Zidane’s plan to put Casemiro on him with Ramos and Raphael Varane as back up.
But Ramos is ready to take things into his own hands to keep the title race alive.
Messi has been on fire for Barca this season, scoring 14 goals in 16 La Liga games.
He has inspired Barcelona, who seemed in crisis before the season started, to a six point lead.
They have scored 42 goals in 16 games with a goal difference of plus 35.